If you have questions about which vaccine is best for you, talk to your doctor or other health care professional. stream Fluzone Quadrivalent should not be combined through reconstitution or mixed with any other vaccine. The vaccine should not be injected into the gluteal area or areas where there may be a major nerve trunk. Participants were monitored for unsolicited adverse events and SAEs during the 28 days following vaccination. Vaccination of female rabbits with Fluzone Quadrivalent revealed no evidence of impaired female fertility [see Animal Data (8.1)]. Southern Hemisphere. 8.2 Lactation Could the Flu Shot Lower Your Risk for Alzheimer's? Women who receive Fluzone Quadrivalent Southern Hemisphere during pregnancy are encouraged to contact Sanofi Pasteur Inc. directly or have their healthcare provider contact Sanofi Pasteur Inc. at 1-800-822-2463. Fluzone® Quadrivalent Participants received one dose of either Fluzone vaccine (N = 813), an active comparator (N = 814), or placebo (N = 325). Therefore, influenza vaccines are standardized to contain the hemagglutinins of influenza virus strains representing the influenza viruses likely to be circulating during the influenza season in the hemisphere for which the vaccine is intended. Fluzone Quadrivalent Southern Hemisphere suspension for injection is clear and slightly opalescent in color.
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Healthcare providers are encouraged to enroll women who receive Fluzone Quadrivalent during pregnancy in Sanofi Pasteur Inc.'s vaccination pregnancy registry by calling 1-800-822-2463. exclamation square light iconGetting a flu vaccine is more important than ever during 2020-2021 to protect yourself and the people around you from flu, and to help reduce the strain on healthcare systems responding to the COVID-19 pandemic. ��V���S�Fӈ�)%.`,Er D"�"�atZ����2t]�7 _�/�e��S=���0�?bD��J9#r�˄����' á�. The effectiveness of Fluzone Quadrivalent was demonstrated based on clinical endpoint efficacy data for Fluzone (trivalent influenza vaccine) and on an evaluation of serum HI antibody responses to Fluzone Quadrivalent. A randomized, double-blind, placebo-controlled study was conducted in a single US center during the 2007-2008 influenza season. Fluzone ® Quadrivalent Southern Hemisphere is a vaccine indicated for active immunization for the prevention of influenza disease caused by influenza A subtype viruses and type B viruses contained in the vaccine.. Fluzone Quadrivalent Southern Hemisphere is approved for use in persons 6 months of age and older. Fluzone Quadrivalent Southern Hemisphere (Influenza Vaccine) for intramuscular injection is an inactivated influenza vaccine, prepared from influenza viruses propagated in embryonated chicken eggs. Unsolicited non-serious adverse events were reported in 33 (17.4%) recipients in the Fluzone Quadrivalent group, 45 (23.7%) recipients in the TIV-1 group, and 45 (23.7%) recipients in the TIV-2 group. 2 Helping to protect against both influenza A and B viruses is important because both types are responsible for a substantial amount of flu-related hospitalizations and complications. Another study published in The Lancet Respiratory Medicineexternal icon reported that Fluzone High-dose was associated with a lower risk of hospital admissions compared with standard-dose Fluzone in adults 65 years and older, especially those living in long-term care facilities. Annual vaccination with the influenza vaccine is recommended because immunity during the year after vaccination declines and because circulating strains of influenza virus change from year to year. Fluzone Quadrivalent, an inactivated influenza vaccine that contains the hemagglutinins of two influenza A subtype viruses and two influenza type B viruses, is manufactured according to the same process as Fluzone. Prior to vaccination, always refer to the current Advisory Committee on Immunization Practices annual recommendations on prevention and control of influenza. Each of the trivalent formulations contained an influenza type B virus that corresponded to one of the two type B viruses in Fluzone Quadrivalent (a type B virus of the Victoria lineage or a type B virus of the Yamagata lineage). GMT ratios (GMT0.5-mL dose divided by GMT0.25-mL dose) for the A/H1N1, A/H3N2, B Victoria lineage, and B Yamagata lineage strains were 1.42 (95% CI: 1.16; 1.74), 1.48 (95% CI: 1.21; 1.82), 1.33 (95% CI: 1.09; 1.62), and 1.41 (95% CI: 1.17; 1.70), respectively. Fluzone Quadrivalent has not been evaluated for carcinogenic or mutagenic potential, or for impairment of male fertility in animals. Participants were monitored for unsolicited adverse events for 28 days after each dose and serious adverse events (SAEs) during the 6 months following the last dose. In the follow-up period, there were two SAEs, 1 (0.5%) in the Fluzone Quadrivalent group and 1 (0.5%) in the TIV-2 group.
Appropriate medical treatment and supervision must be available to manage possible anaphylactic reactions following administration of Fluzone Quadrivalent Southern Hemisphere. The most commonly reported unsolicited non-serious adverse events in both groups were cough and rhinorrhea. What is the difference between Fluzone High-Dose Quadrivalent and Fluzone Quadrivalent? Both these products are flu vaccines produced by the same manufacturer.
Influenza-like illness was defined as fever with signs or symptoms of an upper respiratory infection. Available for Android and iOS devices. This study was conducted during the 2013-14 flu season among more than 38,000 resident of 823 nursing homes in 38 states. In adults 18 years and older, the most common (≥10%) injection-site reaction was pain (47%); the most common solicited systemic adverse reactions were myalgia (24%), headache (16%), and malaise (11%). In the United States, Fluzone High-Dose Quadrivalent is licensed only for persons aged 65 years and older. The dose and schedule for Fluzone Quadrivalent Southern Hemisphere are presented in Table 1. Vaccine efficacy against all influenza viral types and subtypes was a secondary endpoint and is presented in Table 8.
Global surveillance of influenza identifies yearly antigenic variants. For participants who received two doses, the doses were administered approximately 4 weeks apart.