Health professionals also need to stay up to date with the latest evidence as it emerges. The safety of LAIV in people with a history of asthma, diabetes mellitus, or other high-risk medical conditions associated with an elevated risk of complications from influenza (see Contraindications and Precautions) has not been firmly established. NPS MedicineWise disclaims all liability (including for negligence) for any loss, damage or injury resulting from reliance on or use of this information. Clin Infect Dis 2009;48:1003-32. Pharmacokinetic analysis did not identify a clinically meaningful effect of renal function on the pharmacokinetics of baloxavir in patients with creatinine clearance 50 mL/min and above. Most (66%) of those children died after being admitted to the hospital. In each instance, the recommended volume may be administered from an appropriate prefilled syringe, a single-dose vial, or multidose vial, as supplied by the manufacturer.
Superior immune responses to the trivalent unmatched strains were found.Fluad (MF59-adjuvant) elicited significantly higher antibody responses compared to a non-adjuvanted trivalent vaccine in older people, including those with underlying medical conditions. Empiric antiviral treatment should be started as soon as possible in the above priority groups.Clinicians can consider early empiric antiviral treatment of non-high-risk outpatients with suspected influenza [e.g., influenza-like illness (fever with either cough or sore throat)] based upon clinical judgement, if treatment can be initiated within 48 hours of illness onset.During periods of community co-circulation of influenza viruses and SARS-CoV-2, empiric antiviral treatment of influenza is recommended as soon as possible for the following priority groups: a) hospitalized patients with respiratory illness; b) outpatients with severe, complicated, or progressive respiratory illness; and c) outpatients at higher risk for influenza complications who present with any acute respiratory illness symptoms (with or without fever).Abbreviations: N/A = not applicable, COPD = chronic obstructive pulmonary disease.Complete footnotes for this algorithm are.The following recommendations do not necessarily represent FDA-approved uses of antiviral products but are based on published observational studies and expert opinion and are subject to change as the developmental status of investigational products and the epidemiologic and virologic features of influenza change over time.Dose adjustment of oseltamivir is recommended for patients with creatinine clearance between 10 and 60 mL/min and patients with end-stage renal disease (ESRD) undergoing hemodialysis or continuous peritoneal dialysis receiving oseltamivir for the treatment or chemoprophylaxis of influenza. The median age of the pediatric deaths was 6.1 years (range: 2 months–17 years).○ A total of 107 were associated with influenza A viruses: 43 with influenza A(H1N1)pdm09, 25 with A(H3N2), and 39 with an influenza A virus for which no subtyping was available.○ Eight were associated with influenza B viruses.○ One was associated with an undetermined type of influenza virus.Among the 104 children with known medical history, 51% of deaths occurred in children who had at least 1 underlying medical condition recognized by the Advisory Committee on Immunization Practices (ACIP) to increase the risk of influenza-attributable disease severity. The information on this page should be considered current for the 2020-2021 influenza season for clinical practice regarding the use of influenza antiviral medications. Available at:Influenza vaccine effectiveness against pediatric deaths: 2010-2014,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network,Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012,members of the Canadian Immunization Monitoring Program Active,Committee on Practice and Ambulatory Medicine,Immunizing parents and other close family contacts in the pediatric office setting,Early use of anti-influenza medications in hospitalized children with tracheostomy,Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season.Recommended composition of influenza virus vaccines for use in the 2019-2020 northern hemisphere influenza season. If you get sick with flu, antiviral drugs may be a treatment option. The influenza vaccine can be administered at any stage of pregnancy.It is particularly important that healthcare providers in hospitals and general practices are vaccinated, given their likely exposure to individuals with influenza. Although the use of LAIV in young children with chronic medical conditions, including asthma, has been implemented outside of the United States, data are considered insufficient to support an expanded recommendation in the United States.The CDC conducted a systematic review of published studies evaluating the effectiveness of LAIV3 and LAIV4 in children from the 2010–2011 to the 2016–2017 seasons, including data from US and European studies.For the 2017–2018 season, a new A(H1N1)pdm09-like virus (A/Slovenia/2903/2015) was included in LAIV4, replacing A/Bolivia/559/2013. 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This includes the following:Influenza in pregnancy is associated with an increased risk of maternal morbidity and mortality, along with preterm delivery.