has 30-plus years of international experience treating alcohol and drug addiction. Microbiology. Prior to joining Bradford, Way worked in IT leadership roles with Acuity Brands, Walter Energy, and most recently Alacare Home Health and Hospice. Julia Hughes CYP450 enzymes. Bradford is “in-network” with all major insurance providers and is a leader in finding ways to make effective treatment affordable. She and her three-member team make sure that the complex needs of health professionals in our care are being met. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B978012374005200096X, URL: https://www.sciencedirect.com/science/article/pii/B9780128006344000305, URL: https://www.sciencedirect.com/science/article/pii/B9780128006344000421, URL: https://www.sciencedirect.com/science/article/pii/B9780123750006000902, URL: https://www.sciencedirect.com/science/article/pii/B9780444814449500183, URL: https://www.sciencedirect.com/science/article/pii/B9780124171442000020, URL: https://www.sciencedirect.com/science/article/pii/B9780124186798000083, URL: https://www.sciencedirect.com/science/article/pii/B9780444537171010556, URL: https://www.sciencedirect.com/science/article/pii/S0065291118300201, URL: https://www.sciencedirect.com/science/article/pii/B9780123869456000111, Treatment Planning in Dentistry (Second Edition), 2007, Why Do Some Patients Seem to Develop Tolerance to AEDs? This site provides content for informational purposes only. With dependence, if the drug isn’t present or the dose is suddenly reduced, you might experience withdrawal. selected breeding lines or transgenic manipulations) can be superimposed upon these models to reflect gene–environment interactions upon factors mediating addiction processes (i.e. https://www.ncbi.nlm.nih.gov/pubmed/27080241. The effects of some drugs such as anticancer drugs are not evaluated. The treatment duration can last months, years, or a lifetime. We also address the actual and potential utility of these imaging approaches in both discovery and development of medicines to combat substance abuse. The following example underscores the subtle difference between addiction and dependence: Many people dependent on caffeine experience withdrawal effects, such as headaches, fatigue, and irritability, if they miss their morning cup, but this would not cause them to behave irrationally to obtain it.
His specializations include developing substance-abuse resources on college campuses, enhancing resilience in young adults, substance abuse/dependency among young adults, and parental and young-adult relationships in addicted families. The development of tolerance with a specific drug can vary between different people (there is a genetic influence); with other drugs a person is taking; and with underlying medical conditions that are present. With tolerance, certain cell receptors in the body that activate when the drug is present stop responding like they once did. controlled administration schedule) of the preclinical models to be paralleled; however, ethical considerations limit the applicability of such models in healthy subjects. strain) can undermine the generalizability of findings. He later earned his M.S. Here are some facts about drug tolerance: The main types of drug tolerance include: This is genetically determined by a lack of sensitivity toward a drug when it is first administered. In order to probe the central pharmacology underlying the effects of abused substances (and the treatment thereof), neuroimaging studies can be performed both in experimental models and directly in the target population.
As corporate director, he’s part of a team that develops and oversees clinical programs and services at all of Bradford’s locations. Early in her career, she found that she enjoyed the healthcare culture, which offered the opportunity to focus on financial performance, planning and operations in an industry whose mission is to promote health, quality and service. 2019;245:488-497. doi:10.1016/j.jad.2018.10.357, Moran TP, Burks AW. (4). Corporate Compliance Officer. Drug resistance is the unresponsiveness of microorganisms to an antimicrobial agent after repeated use. One half of the METH users had values in substantia nigra higher than the upper limit of the control range (Figure 16). Tolerance is common. (2012).).