Preventive measures against Marburg virus infection are not well defined, as transmission from wildlife to humans remains an area of ongoing research. Hypotension and shock may require early administration of vasopressors and haemodynamic monitoring with attention to fluid and electrolyte balance, circulatory volume, and blood pressure. The disease may have surfaced as early as March 2004 in a crowded children's ward. To make the vaccines the scientists fused a surface protein from the viruses they hope to protect against onto an animal virus - vesicular stomatitis - which is thought to be of no threat to humans. Thirty-one people became ill, initially laboratory workers followed by several medical personnel and family members who had cared for them.
Diagnosis is made by reverse transcriptase polymerase chain reaction (RT-PCR) from blood or buccal (oral) swab, often by a reference laboratory. Fatal cases usually exhibit some form of bleeding, often from multiple sites. Marburg contains a single molecule of linear negative-sense, 19100 nucleotides long, single-stranded RNA. Marburg originated in Central and East Africa, and infects both human and nonhuman primates We use cookies to collect information about how you use GOV.UK. Signs of bleeding are rare and associated with late disease. The incubation period of Marburg haemorrhagic fever is 3 to 10 days.
There is as yet no licensed treatment proven to neutralize the virus but a range of blood products, immune therapies and drug therapies are currently under development. By July 2005, Angola's health department reported more than 300 cases were fatal. ''Ebolavirus'', ''Marburgvirus'') in addition to renaming the only species in the ''Marburgvirus'' genus from ''Marburg virus'' to ''Lake Victoria Marburgvirus''. All content is available under the Open Government Licence v3.0, except where otherwise stated, Ebola and Marburg haemorrhagic fevers: outbreaks and case locations, The UK has specialist guidance on the management (including infection control) of patients with viral haemorrhagic fevers, ACDP algorithm and guidance on management of patients, Lassa fever: origins, reservoirs, transmission and guidelines, Viral haemorrhagic fevers: epidemiology, characteristics, diagnosis and management, Viral haemorrhagic fevers: origins, reservoirs, transmission and guidelines, Crimean-Congo haemorrhagic fever: origins, reservoirs, transmission and guidelines, High consequence infectious diseases (HCID), Ebola virus disease: clinical management and guidance, Coronavirus (COVID-19): guidance and support, Transparency and freedom of information releases. A few research groups are working on drugs and vaccines to fight the virus. Keywords: Marburg virus, filovirus, vesicular stomatitis virus, vaccine, treatment, viruses, dispatch The filoviruses, Marburg virus (MBGV) and Ebola virus (EBOV), have been associated with sporadic episodes of hemorrhagic fever (HF) in Central Africa that produce severe disease and high mortality rates among infected patients ( 1 ). The tests were conducted by the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). http://www.cdc.gov/vhf/marburg/pdf/factsheet.pdf
There is no specific treatment; historical fatality rates have been as high as 90% and, based on recent experience with Ebola, may be improved with aggressive supportive care and fluid resuscitation.
In 2000, another proposal was made in Washington DC to change the "-like viruses" to "-virus" (e.g. Sexual transmission of the virus can occur, and Marburg virus may remain in semen for up to 7 weeks after clinical recovery. You can change your cookie settings at any time. The disease is spread through bodily fluids, including blood, excrement, saliva, and vomit. Marburg virus is one of two viruses of the Filovirus family which, along with Ebola virus, can cause a severe and fatal haemorrhagic fever (VHF). One innovation in the Angola outbreak has been the use of a portable laboratory operated by a team of Canadian doctors and technicians. According to the company, all animals in the control group died within days whereas all animals that received the regular dosage of the vaccine were fully protected. Cases reported in 5 provinces, the majority in Uige.